Vetenskapligt bevis
Forskare hos Danone Research Centre, i Frankrike, har i mer än 15 år jobbat med
internationella forskningsinstitut världen över. Över 37 studier har genomförts
som alla bidrar med de vetenskapliga bevisen bakom de positiva effekterna av L.
Casei på kroppens försvar.
Studier på Lactobacillus casei DN-114 001 från Danone
The effect of supplementation with milk fermented by Lactobacillus casei (strain
DN-114 001) on acute diarrhoea in children attending day care centres
CA. Pedone, AO. Bernabeu, ER. Postaire, CF. Bouley, P. Reinert Int J Clin Pract,
Apr-May 1999 ; 53 (3) : 179-184
Multicentric study of the effect of milk fermented by Lactobacillus casei on
the incidence of diarrhoea
CA. Pedone, CC. Arnaud, ER. Postaire, CF. Bouley and P. Reinert Int J Clin Pract,
Nov 2000 ; 54 (9) : 568-571
Feasibility studies to control acute diarrhoea in children by feeding fermented
milk preparations Actimel and Indian Dahi
KN Agarwal and S K Bhasin European Journal of Clinical Nutrition (2002) 56, Suppl
4, S56-S59.
Effect of fermented milk containing the probiotic Lactobacillus casei DN-114
001 on winter infections in free-living elderly subjects: a randomised, controlled
pilot study
P. Turchet, M. Laurenzano, S. Auboiron, J. M. Antoine Journal of Nutrition, Health
and Ageing, 2003 ; 7 (2) : 75-77
Enhancement of host resistance against Salmonella typhimurium in mice fed a
diet supplemented with yogurt or milks fermented with various Lactobacillus casei
strains
M. Paubert-Braquet, Xiao-Hu Gan, C. Gaudichon, N. Hedef, A. Serikoff, C. Bouley,
B. Bonavida and P. Braquet Int. J. Immunotherapy, 1995 ; XI (4) : 153-161
Food supplementation with milk fermented by Lactobacillus casei DN-114 001 protects
suckling rats from Rotavirus-associated diarrhea
C. Guérin-Danan, JC. Meslin, A. Chambard, A. Charpilienne, P. Relano, C. Bouley,
J. Cohen and C. Andrieux J Nutr, Jan 2001 ; 131 (1) : 111-117
Effect of fermented milk containing probiotic bacteria in the prevention of
an enteroinvasive Escherichia coli infection in mice.
Medici M, Vinderola CG, Weill R, Perdigon G. J Dairy Res. 2005 May;72(2):243-9.
Effects of a Specially Designed Fermented Milk Product Containing Probiotic
Lactobacillus casei DN-114 001 and the Eradication of H. pylori in Children
Sykora J,Valeckova K , Amlerova J, Siala K, Dedek P, Watkins S,Varvarovska J, Stozicky
F, Pazdiora P, Schwarz J. J Clin Gastr 2005 ; 39 : 692–698.
The effect of fermented yogurt on the prevention of diarrhea in a healthy adult
population.
Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M. Am-J-Infect-Control, Mar
2005, vol. 33, no. 2, p. 122-5.
Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with
antibiotics: randomised double blind placebo controlled trial.
Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ. Nutrition
and Dietetic Research Group, Faculty of Medicine, Imperial College, London W12 0HS.
The association of yogurt staters with Lactobacillus casei DN-114 001 in fermented
milk alters the composition and metabolism of intestinal microflora in germ-free
rats and in human flora-associated rats
Z. Djouzi, C. Andrieux, M.-C. Degivry, C. Bouley and O. Szylit J Nutr., 1997, 127
: 2260-2266
Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt
and gelled milk: influence on intestinal microflora in healthy infants
C. Guerin-Danan, C. Chabanet, C. Pedone, F. Popot, P. Vaissade, C. Bouley, O. Szylit
and C. Andrieux Am J Clin Nutr, 1998 ; 67 : 111-117
Modulation of proliferation, second messenger levels, and morphotype expression
of the rat intestinal epithelial cell line IEC-6 by fermented milk
K. Thoreux, F. Senegas-Balas, F. Bernard-Perrone, S. Giannarelli, G. Denariaz, C.
Bouley and D. Balas J. Dairy Sci., 1996, 79 : 33-43
Diet supplemented with yoghurt or milk fermented by Lactobacillus casei DN-114
001 stimulates growth and brush-border enzyme activities in mouse small intestine
K.Thoreux, D. Balas, C. Bouley and F. Senegas-Balas Digestion, 1998, 59 : 349-359
Host-pathogens cross-talk. Indigenous bacteria and probiotics also play the
game
Miguel Freitas, Emmanuelle Tavan, Chantal Cayuela, Laurent Diop, Catherine Sapin,
Germain Trugnan Biology of the Cell, 2003, Vol 95, Issue 8, pp. 503-6
Lactobacillus casei DN-114 001 inhibits the increase of paracellular permeability
in enteropathogenic Escherichia coli-infected T84 cells
Nadège Parassol, Miguel Freitas, Karine Thoreux , Guillaume Dalmasso, Raphaelle
Bourdet-Sicard, Patrick Rampal Research in Microbiology, 2005, Vol 156, Issue 2,
Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive E.
coli isolated from Crohn’s disease patients to adhere to and to invade intestinal
epithelial cells
Isabelle Ingrassia, Antony Leplingard, Arlette Darfeuille-Michaud A Appl. Environ.
Microbiol,2005, 71, 2880-2887.
The effect of fermented milk containing Lactobacillus casei on the immune response
to exercise
P. Pujol, J. Huguet, F. Drobnic, M. Banquells, O. Ruiz, P. Galilea, N. Segarra,
S. Aguilera, A. Burnat, JA. Mateos and E. Postaire Training and Rehab., 2000, 9[3],
The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114
001 on the immune response of subjects under academic examination stress
Ascensión Marcos, Julia Wärnberg, Esther Nova PhD, Sonia Gómez, Alberto Alvarez,
Rocío Álvarez, José A. Mateos, José M Cobo Eur J Nutr 2004;43(6):381-9
Monocyte function in healthy middle-aged people receiving fermented milk containing
lactobacillus casei
D. Parra, B. Martinez de Morentin, J.M. Cobo, A. Mateos, J. A. Martinez The Journal
of Nutrition, Health & Aging; 2004, Vol 8, N° 4; pp. 208-211
Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves
innate-defense capacity in healthy middle-aged people.
M. D. Parra, B. E. Martinez de Morentin, J.M. Cobo, A. Mateos, J. A. Martinez J.
Physiol. Biochem.; 2004, Vol 60, N° 2; pp. 85-92
Increased mucosal TNF α production in Crohn's disease can be downregulated ex
vivo by probiotic
N. Borruel, M. Carol, F. Casellas, M. Antolín, F. de Lara, E. Espín, J. Naval, F.
Guarner and J. R. Malagelada. Gut, 2002 ; 5 : 659-664
Effects of non pathogenic bacteria on cytokine secretion by human intestinal
mucosa
N. Borruel, F. Casellas, M. Antolín, M. Llopis, M. Carol, E. Espín, J. Naval, F.
Guarner and J. R. Malagelada. Am. J. Gastro., 2003, 98[4] : 865-870
Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation
Ludivine Chapat, Karine Chemin, Bertrand Dubois, Raphaëlle Bourdet-Sicard and Dominique
Kaiserlian European Journal of Immunology, 2004, 34: 2520-2528
Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced
by exposure to trinitronbenzene sulphonic acid.
Llopis M, Antolin M, Guarner F, Salas A, Malagelada JR. Gut. 2005 Jul;54(7):955-9.
Oral administration of probiotic bacteria (E. coli Nissle, E. coli O83, Lactobacillus
casei) influences the severity of dextran sodium sulfate-induced colitis in BALB/c
mice.
Kokesová A, Frolová L, Kverka M, Sokol D, Rossmann P, Bártová J, Tlaskalová-Hogenová
H. Clinic of Pediatric Surgery, University Children Hospital Motol, 150 06 Prague,
Czechia.
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal
epithelial cells.
Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppée JY, Bourdet-Sicard
R, Sansonetti PJ, Pédron T.
Pathogénie Microbienne Moléculaire Unit, Institut National de la Santé et de la
Recherche Médicale U389, Paris, France.
Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in
Crohn's disease.
Carol M, Borruel N, Antolin M, Llopis M, Casellas F, Guarner F, Malagelada JR. Digestive
System Research Unit, University Hospital Vall d'Hebron, Autonomous University of
Barcelona, Barcelona, Spain. mcarol@vhebron.net
Lactobacillus casei is able to survive and initiate protein synthesis during
its transit in the digestive tract of human flora-associated mice
R. Oozeer, N. Goupil-Feuillerat, CA. Alpert, M. van de Guchte, J. Anba, J. Mengaud
and G. Corthier Appl. Envir. Microbiol., 2002, 68 : 3570-3574
Initiation of protein synthesis by a labeled derivative of the Lactobacillus
casei DN-114 001 strain during its transit from the stomach to the cecum in Human
Microbiota-Associated mice.
R. Oozeer, D.D.G Mater, N. Goupil-Feuillerat, G. Corthier Appl. Envir. Microbiol.,
2004, 70 : 6992-6997
Differential Activities of Four Lactobacillus casei Promoters during Bacterial
Transit through the Gastrointestinal Tract of Human-Microbiota-Associated Mice.
R. Oozeer, JP. Furet, N. Goupil-Feuillerat, J. Anba, J. Mengaud, G. Corthier Appl.
Envir. Microbiol, 2005, 71(3): 1356-63
Survival of Lactobacillus casei in the human digestive tract after consumption
of fermented milk.
Oozeer-R, Leplingard-A, Mater-D-D-G, Mogenet-A, Michelin-R, Seksek-I, Marteau-P,
Dore-J, Bresson-J-L, Corthier-G. Appl Environ Microbiol. 2006 Aug;72(8):5615-7
Effects of orally administered Lactobacillus casei DN-114 001 on the composition
or activities of the dominant faecal microbiota in healthy humans.
Violaine Rochet, Lionel Rigottier-Gois, Malène Sutren, Marie-Noelle Krementscki,
Claude Andrieux,Jean-Pierre Furet, Patrick Tailliez, Florence Levenez, Agnès Mogenet,
Jean-Louis Bresson, Séverine Méance, Chantal Cayuela, Antony Leplingard and Joel
Doré. British Journal of Nutrition. 2006. 95, 421–429.